Screening plates identify optimum scavengers
Biotage announces the introduction of ExploraSep 96-well screening plates to identify optimum scavengers. The four different screening plates deliver 128 selective resins based on high-performance, molecularly imprinted polymers (MIP).
Biotage provides professional MIP technical consultation, information on additional formats as well as assistance with data interpretation and process development.
The screening plates support rapid method development, reduced cycle times and allow the identification of selective MIP for impurities such as genotoxins; currently a major concern for the pharmaceutical industry. Candidate MIP identified during screening can be ordered separately for confirmation studies and then transferred to preparative or process scale applications.
The plates contain a unique collection of proprietary separation phases based on MIP and their non-imprinted homologs. The polymers are grouped so that each plate is themed and will target a particular class of impurities.
Plate A can be used for screening polar, basic (eg amines), neutral (eg amides, or esters), and acidic (carboxylic acid) compounds. Plate U targets screening phosphates, phosphonates, sulphates and sulphonates, peptides, proteins as well as anions of carboxylic acids and more weakly binding lactones and neutral phosphates. Plate C can be used for screening 1,2- and 1,3-diols, a-hydroxycarboxylic acids, carbohydrates and hydrophillic peptides under basic conditions. Plate H polymers target non-polar and aromatic compounds.
Like a lock and key, molecularly imprinted polymers bind impurities, not just by chemical means, but also by spatial recognition. This dual-mechanism enables MIP to be highly selective, working effectively at very low concentrations, getting down to very low impurity levels. In increasingly challenging regulatory climates, MIP show excellent promise for being able to keep up with ever-tightening regulations.
