New desiccant closure system for HDPE pharmaceutical bottles
Dated: 5/12/2008
Multisorb Technologies says it has partnered with Neutroplast Indústria de Embalagens Plásticas, S.A to offer a Multiform Coated Solid Form (CSF) Closure System for high-density polyethylene (HDPE) pharmaceutical bottles.
The system combines Multisorb’s Multiform CSF concentrated desiccant with Neutroplast’s screw closure.
With other similar closure systems, desiccant function is compromised by moisture from the drug product that utilizes initial adsorptive capacity immediately after packaging.
The Multiform CSF Closure System overcomes this deficiency by offering twice the desiccant capacity, protecting the drug product from moisture-mediated degradation while also functioning as an active barrier system, inhibiting moisture ingress through the bottle–closure system joint.
The Multiform CSF is a compact silica gel desiccant that utilizes condensed density technology.
Fitted into the Neutroplast’s screw closure as part of the container closure system, it serves as an active barrier, adsorbing moisture ingress rather than merely blocking it as in static barrier systems.
The closure system’s desiccant offers double the amount of adsorbent capacity per cubic centimeter of space compared to similarly sized silica gel desiccants.
It actively desiccates the product to reduce the rate of chemical degradation and stabilize the drug formulation during storage and transport.
The Multiform CSF has a pharmaceutical grade coating that allows for direct product contact and can be manufactured under advanced aseptic conditions.
It has a Drug Master File available and is constructed with FDA-approved materials.
